Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10939.143 | 1.0209 | 1.0237 | 1.7568 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10939.143 | 0.9229 | 0.9107 | 1.7568 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10939.143 | 0.9615 | 0.9558 | 1.7568 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10939.143 | 0.9532 | 0.9462 | 1.7568 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10939.143 | 0.6223 | 0.5268 | 1.7568 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10939.143 | 0.0187 | -0.7921 | 1.7568 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12608.143 | 1.0121 | 1.0214 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.192 | uM | 12608.143 | 0.9719 | 0.9503 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.96 | uM | 12608.143 | 1.0182 | 1.0321 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 4.8 | uM | 12608.143 | 0.9624 | 0.9335 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 24 | uM | 12608.143 | 1.0126 | 1.0222 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 120 | uM | 12608.143 | 0.9859 | 0.9750 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 600 | uM | 12608.143 | 0.8785 | 0.7838 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 3000 | uM | 12608.143 | 0.5728 | 0.2226 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 15000 | uM | 12608.143 | 0.0179 | -0.9427 | 1.1322 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10580.143 | 0.9827 | 0.9588 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10580.143 | 0.9658 | 0.9188 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10580.143 | 0.9475 | 0.8756 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10580.143 | 0.9209 | 0.8131 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10580.143 | 0.9426 | 0.8642 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10580.143 | 0.9759 | 0.9427 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10580.143 | 0.9043 | 0.7744 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10580.143 | 0.7186 | 0.3497 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10580.143 | 0.3788 | -0.3701 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10754.143 | 1.0198 | 1.0327 | 1.2072 |