Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10754.143 | 0.8928 | 0.8207 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10754.143 | 0.9897 | 0.9828 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10754.143 | 0.8552 | 0.7569 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10754.143 | 1.0009 | 1.0016 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10754.143 | 0.9741 | 0.9571 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10754.143 | 0.8147 | 0.6878 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10754.143 | 0.7131 | 0.5115 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10754.143 | 0.3388 | -0.1840 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 11938.143 | 0.9747 | 0.9048 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 11938.143 | 0.9762 | 0.9105 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 11938.143 | 1.0172 | 1.0660 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 11938.143 | 1.0332 | 1.1281 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 11938.143 | 0.9753 | 0.9072 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 11938.143 | 0.9586 | 0.8454 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 11938.143 | 0.9748 | 0.9053 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 11938.143 | 0.8976 | 0.6286 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 11938.143 | 0.4895 | -0.4860 | 0.5258 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 11660.143 | 0.9697 | 0.9416 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 11660.143 | 0.9325 | 0.8699 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 11660.143 | 0.9644 | 0.9315 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 11660.143 | 0.9799 | 0.9612 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 11660.143 | 0.9375 | 0.8795 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 11660.143 | 0.9982 | 0.9965 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 11660.143 | 0.9508 | 0.9052 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 11660.143 | 0.7042 | 0.4271 | 1.0389 |