Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 120 | uM | 11058.143 | 0.9665 | 0.9711 | 2.3374 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 600 | uM | 11058.143 | 0.8903 | 0.9030 | 2.3374 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 3000 | uM | 11058.143 | 0.4630 | 0.4386 | 2.3374 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 15000 | uM | 11058.143 | 0.0168 | -0.6515 | 2.3374 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10695.143 | 1.0815 | 1.1253 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10695.143 | 0.9538 | 0.9280 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10695.143 | 1.0702 | 1.1080 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10695.143 | 1.0369 | 1.0570 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10695.143 | 1.0610 | 1.0939 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10695.143 | 0.9902 | 0.9848 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10695.143 | 0.8849 | 0.8190 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10695.143 | 0.4032 | -0.0113 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10695.143 | 0.0197 | -0.9049 | 1.2894 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 11852.143 | 1.0397 | 1.0644 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 11852.143 | 1.0382 | 1.0619 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 11852.143 | 1.0488 | 1.0790 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 11852.143 | 0.9976 | 0.9961 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 11852.143 | 1.0424 | 1.0687 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 11852.143 | 1.0072 | 1.0116 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 11852.143 | 0.8510 | 0.7538 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 11852.143 | 0.3637 | -0.1221 | 1.2284 | |
| SUM52PE | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 11852.143 | 0.0200 | -0.9172 | 1.2284 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10939.143 | 0.9739 | 0.9701 | 1.7568 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10939.143 | 0.9567 | 0.9503 | 1.7568 | |
| T47D | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10939.143 | 0.6957 | 0.6268 | 1.7568 |