Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.000171 | uM | 12220.158 | 0.9097 | 0.6056 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.000853 | uM | 12220.158 | 1.0703 | 1.3418 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.00427 | uM | 12220.158 | 1.1382 | 1.7011 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0213 | uM | 12220.158 | 1.0833 | 1.4082 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.107 | uM | 12220.158 | 1.0356 | 1.1690 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.533 | uM | 12220.158 | 1.1100 | 1.5485 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 2.67 | uM | 12220.158 | 1.0853 | 1.4187 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 13.3 | uM | 12220.158 | 0.6387 | -0.2937 | 0.4308 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 66.7 | uM | 12220.158 | 1.1736 | 1.9000 | 0.4308 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11851.158 | 0.9280 | 0.8976 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 11851.158 | 1.0169 | 1.0238 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 11851.158 | 0.9635 | 0.9484 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 11851.158 | 0.9996 | 0.9994 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 11851.158 | 0.9006 | 0.8580 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 11851.158 | 0.9020 | 0.8600 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 11851.158 | 0.7955 | 0.7027 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 11851.158 | 0.7983 | 0.7070 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 11851.158 | 0.6365 | 0.4556 | 1.4217 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10875.153 | 0.9621 | 0.9107 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10875.153 | 1.0468 | 1.1111 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10875.153 | 1.0128 | 1.0302 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10875.153 | 1.0605 | 1.1438 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10875.153 | 0.9791 | 0.9507 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.267 | uM | 10875.153 | 0.9827 | 0.9591 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 1.33 | uM | 10875.153 | 0.8706 | 0.6976 | 0.8455 |