Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12414.165 | 1.0396 | 1.0633 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12414.165 | 0.9966 | 0.9946 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12414.165 | 0.9696 | 0.9511 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12414.165 | 0.9398 | 0.9028 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12414.165 | 0.9754 | 0.9604 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12414.165 | 0.9184 | 0.8679 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12414.165 | 0.5363 | 0.2130 | 1.2459 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10644.141 | 1.0221 | 1.0988 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10644.141 | 0.9835 | 0.9279 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10644.141 | 1.0616 | 1.2820 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10644.141 | 0.9903 | 0.9575 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.107 | uM | 10644.141 | 0.9993 | 0.9967 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.533 | uM | 10644.141 | 0.9521 | 0.7948 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 2.67 | uM | 10644.141 | 0.9864 | 0.9403 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 13.3 | uM | 10644.141 | 0.6128 | -0.3216 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 66.7 | uM | 10644.141 | 0.1340 | -0.9764 | 0.4530 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10874.153 | 0.9370 | 0.8521 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10874.153 | 0.9562 | 0.8969 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10874.153 | 1.0019 | 1.0045 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10874.153 | 1.0332 | 1.0787 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10874.153 | 0.9520 | 0.8872 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.267 | uM | 10874.153 | 0.9317 | 0.8396 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 1.33 | uM | 10874.153 | 0.8838 | 0.7285 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 6.67 | uM | 10874.153 | 0.9529 | 0.8891 | 0.8467 | |
| MX1 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 33.3 | uM | 10874.153 | 1.0328 | 1.0778 | 0.8467 |