Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12379.165 | 0.9607 | 0.7865 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12379.165 | 0.9932 | 0.9621 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12379.165 | 0.9634 | 0.8005 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12379.165 | 0.9769 | 0.8724 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12379.165 | 0.6516 | -0.4017 | 0.3550 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10938.153 | 1.4005 | 3.4363 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10938.153 | 1.3046 | 2.7510 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10938.153 | 1.4596 | 3.8919 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10938.153 | 1.4268 | 3.6357 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10938.153 | 1.4718 | 3.9888 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10938.153 | 1.3749 | 3.2468 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10938.153 | 1.2448 | 2.3567 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10938.153 | 1.2589 | 2.4476 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10938.153 | 1.1314 | 1.6781 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12333.165 | 0.9741 | 0.9170 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12333.165 | 1.0192 | 1.0621 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12333.165 | 0.8887 | 0.6537 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12333.165 | 0.8688 | 0.5944 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12333.165 | 0.8590 | 0.5656 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12333.165 | 0.8987 | 0.6839 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12333.165 | 0.8935 | 0.6681 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12333.165 | 0.9443 | 0.8235 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12333.165 | 0.8833 | 0.6376 | 0.6207 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12414.165 | 1.0242 | 1.0388 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12414.165 | 0.9694 | 0.9507 | 1.2459 |