Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 12126.158 | 0.9303 | 0.7727 | 0.5992 | |
| MDA-MB-175-VII | HR+ | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 12126.158 | 0.9596 | 0.8668 | 0.5992 | |
| MDA-MB-175-VII | HR+ | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 12126.158 | 0.7448 | 0.2233 | 0.5992 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10643.141 | 1.0021 | 1.0088 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10643.141 | 1.0071 | 1.0295 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10643.141 | 1.0266 | 1.1113 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10643.141 | 1.0277 | 1.1160 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 10643.141 | 0.9934 | 0.9728 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 10643.141 | 0.9679 | 0.8699 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 10643.141 | 0.9868 | 0.9458 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 10643.141 | 0.8374 | 0.3867 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 10643.141 | 0.2809 | -0.8544 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10999.153 | 1.0133 | 1.0403 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10999.153 | 0.9996 | 0.9988 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10999.153 | 1.0172 | 1.0520 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10999.153 | 0.9666 | 0.9001 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10999.153 | 0.9900 | 0.9698 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10999.153 | 1.0021 | 1.0062 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10999.153 | 0.9675 | 0.9027 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10999.153 | 0.9034 | 0.7157 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10999.153 | 0.7619 | 0.3266 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12379.165 | 1.0001 | 1.0004 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12379.165 | 1.0216 | 1.1239 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12379.165 | 1.0009 | 1.0050 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12379.165 | 0.9943 | 0.9678 | 0.3550 |