Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
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MCF 10F | NM | - | AG1478 | EGFR | ErbB | 6.67 | uM | 7872.016 | 0.4156 | 0.1065 | 1.4834 | |
MCF 10F | NM | - | AG1478 | EGFR | ErbB | 33.3 | uM | 7872.016 | 0.4050 | 0.0875 | 1.4834 | |
MCF 10F | NM | - | AG1478 | EGFR | ErbB | 167 | uM | 7872.016 | 0.2917 | -0.1284 | 1.4834 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.000427 | uM | 7491.016 | 0.9927 | 0.9781 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.00213 | uM | 7491.016 | 0.9478 | 0.8446 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.0107 | uM | 7491.016 | 0.9601 | 0.8807 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.0533 | uM | 7491.016 | 0.8539 | 0.5757 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.267 | uM | 7491.016 | 0.5912 | -0.0955 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 1.33 | uM | 7491.016 | 0.3012 | -0.6731 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 6.67 | uM | 7491.016 | 0.3032 | -0.6698 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 33.3 | uM | 7491.016 | 0.1906 | -0.8362 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 167 | uM | 7491.016 | 0.1533 | -0.8820 | 0.6625 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.000427 | uM | 7873.016 | 0.9698 | 0.9717 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.00213 | uM | 7873.016 | 0.9573 | 0.9599 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.0107 | uM | 7873.016 | 0.9899 | 0.9906 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.0533 | uM | 7873.016 | 1.0337 | 1.0310 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 0.267 | uM | 7873.016 | 0.9533 | 0.9560 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 1.33 | uM | 7873.016 | 0.3681 | 0.2569 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 6.67 | uM | 7873.016 | 0.2579 | 0.0653 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 33.3 | uM | 7873.016 | 0.4513 | 0.3818 | 2.1516 | |
MCF12A | NM | Basal B | AG1478 | EGFR | ErbB | 167 | uM | 7873.016 | 0.2682 | 0.0848 | 2.1516 | |
MCF7 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7874.016 | 0.8695 | 0.8321 | 1.5947 | |
MCF7 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7874.016 | 0.9696 | 0.9616 | 1.5947 | |
MCF7 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7874.016 | 0.9708 | 0.9632 | 1.5947 | |
MCF7 | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7874.016 | 0.9799 | 0.9747 | 1.5947 |