Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | AG1478 | EGFR | ErbB | 167 | uM | 7870.016 | 0.1666 | -0.1465 | 2.1045 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.000427 | uM | 7488.016 | 1.0391 | 1.0637 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.00213 | uM | 7488.016 | 0.9668 | 0.9456 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.0107 | uM | 7488.016 | 0.9788 | 0.9653 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.0533 | uM | 7488.016 | 0.9124 | 0.8556 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.267 | uM | 7488.016 | 0.4770 | 0.0923 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 1.33 | uM | 7488.016 | 0.2633 | -0.3277 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 6.67 | uM | 7488.016 | 0.3166 | -0.2185 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 33.3 | uM | 7488.016 | 0.1827 | -0.5014 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 167 | uM | 7488.016 | 0.2183 | -0.4233 | 1.2238 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.000427 | uM | 7871.016 | 1.0721 | 1.1403 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.00213 | uM | 7871.016 | 1.0084 | 1.0164 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.0107 | uM | 7871.016 | 1.0715 | 1.1391 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.0533 | uM | 7871.016 | 0.9731 | 0.9477 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.267 | uM | 7871.016 | 0.6996 | 0.4126 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 1.33 | uM | 7871.016 | 0.4648 | -0.0514 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 6.67 | uM | 7871.016 | 0.4540 | -0.0728 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 33.3 | uM | 7871.016 | 0.4619 | -0.0571 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 167 | uM | 7871.016 | 0.1168 | -0.7528 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.000427 | uM | 7872.016 | 0.9059 | 0.8711 | 1.4834 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.00213 | uM | 7872.016 | 0.9741 | 0.9649 | 1.4834 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.0107 | uM | 7872.016 | 0.9905 | 0.9872 | 1.4834 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.0533 | uM | 7872.016 | 0.9529 | 0.9360 | 1.4834 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 0.267 | uM | 7872.016 | 0.5352 | 0.3122 | 1.4834 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 1.33 | uM | 7872.016 | 0.4095 | 0.0956 | 1.4834 |