Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 1.33 | uM | 7824.016 | 0.8204 | 0.7821 | 1.7164 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 6.67 | uM | 7824.016 | 0.6175 | 0.5103 | 1.7164 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 33.3 | uM | 7824.016 | 0.3239 | 0.0370 | 1.7164 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 167 | uM | 7824.016 | 0.2108 | -0.1925 | 1.7164 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.000427 | uM | 7825.016 | 0.9710 | 0.9648 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.00213 | uM | 7825.016 | 0.9352 | 0.9209 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.0107 | uM | 7825.016 | 1.0054 | 1.0065 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.0533 | uM | 7825.016 | 0.9561 | 0.9466 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.267 | uM | 7825.016 | 0.9581 | 0.9491 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 1.33 | uM | 7825.016 | 0.7927 | 0.7388 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 6.67 | uM | 7825.016 | 0.5837 | 0.4461 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 33.3 | uM | 7825.016 | 0.6998 | 0.6131 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 167 | uM | 7825.016 | 0.5044 | 0.3243 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.000427 | uM | 7827.016 | 0.8674 | 0.8184 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.00213 | uM | 7827.016 | 0.9733 | 0.9641 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.0107 | uM | 7827.016 | 0.8412 | 0.7815 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.0533 | uM | 7827.016 | 0.9338 | 0.9105 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 0.267 | uM | 7827.016 | 0.8112 | 0.7388 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 1.33 | uM | 7827.016 | 0.8330 | 0.7700 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 6.67 | uM | 7827.016 | 0.6330 | 0.4730 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 33.3 | uM | 7827.016 | 0.4829 | 0.2291 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 167 | uM | 7827.016 | 0.2574 | -0.1931 | 1.4950 | |
| HCC1806 | TNBC | Basal A | AG1478 | EGFR | ErbB | 0.000427 | uM | 7829.016 | 0.9956 | 0.9955 | 1.9532 | |
| HCC1806 | TNBC | Basal A | AG1478 | EGFR | ErbB | 0.00213 | uM | 7829.016 | 1.0302 | 1.0307 | 1.9532 | |
| HCC1806 | TNBC | Basal A | AG1478 | EGFR | ErbB | 0.0107 | uM | 7829.016 | 1.0172 | 1.0175 | 1.9532 |