Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7553.066 | 0.9247 | 0.8451 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7553.066 | 0.9215 | 0.8384 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10444.066 | 0.9973 | 0.9940 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 10444.066 | 0.9672 | 0.9287 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 10444.066 | 1.0001 | 1.0002 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 10444.066 | 1.0048 | 1.0105 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 10444.066 | 0.9890 | 0.9762 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 10444.066 | 0.9518 | 0.8953 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 10444.066 | 0.9719 | 0.9390 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 10444.066 | 1.0138 | 1.0300 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 10444.066 | 0.5651 | 0.0751 | 0.9196 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7555.066 | 0.9975 | 0.9971 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7555.066 | 0.9343 | 0.9220 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7555.066 | 1.0126 | 1.0147 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7555.066 | 1.0134 | 1.0156 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7555.066 | 0.9910 | 0.9895 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7555.066 | 0.9747 | 0.9702 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7555.066 | 0.9888 | 0.9869 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7555.066 | 0.9664 | 0.9604 | 1.7081 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7555.066 | 0.9310 | 0.9180 | 1.7081 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7791.016 | 1.0185 | 1.0454 | 0.8138 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7791.016 | 1.0254 | 1.0626 | 0.8138 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7791.016 | 1.0126 | 1.0309 | 0.8138 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7791.016 | 0.9350 | 0.8415 | 0.8138 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7791.016 | 0.9842 | 0.9613 | 0.8138 |