Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7457.066 | 0.9064 | 0.8850 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7457.066 | 0.9062 | 0.8848 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7457.066 | 0.9544 | 0.9446 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7457.066 | 0.9670 | 0.9600 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7457.066 | 0.9186 | 0.9003 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7457.066 | 0.8844 | 0.8574 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7457.066 | 0.8017 | 0.7507 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7457.066 | 0.8311 | 0.7890 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7457.066 | 0.1770 | -0.2953 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 10469.066 | 0.9375 | 0.9223 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 10469.066 | 0.9489 | 0.9366 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 10469.066 | 0.9864 | 0.9833 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 10469.066 | 1.0083 | 1.0102 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10469.066 | 0.9824 | 0.9784 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 10469.066 | 0.9153 | 0.8944 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 10469.066 | 0.8510 | 0.8116 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 10469.066 | 0.7968 | 0.7398 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10469.066 | 0.0780 | -0.5820 | 1.6299 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7458.066 | 1.0295 | 1.1623 | 0.3722 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7458.066 | 1.1933 | 2.2152 | 0.3722 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7458.066 | 1.0058 | 1.0313 | 0.3722 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7458.066 | 0.9276 | 0.6343 | 0.3722 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7458.066 | 1.0153 | 1.0834 | 0.3722 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7458.066 | 0.9452 | 0.7187 | 0.3722 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7458.066 | 0.9603 | 0.7939 | 0.3722 |