Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5910.066 | 1.0698 | 1.0443 | 3.0773 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5910.066 | 0.9762 | 0.9844 | 3.0773 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5910.066 | 1.0195 | 1.0126 | 3.0773 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5910.066 | 1.0426 | 1.0273 | 3.0773 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5910.066 | 1.0290 | 1.0187 | 3.0773 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5910.066 | 0.8923 | 0.9273 | 3.0773 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5910.066 | 0.3284 | 0.3927 | 3.0773 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5911.066 | 0.8873 | 0.8164 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5911.066 | 0.9249 | 0.8781 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5911.066 | 0.9155 | 0.8628 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5911.066 | 0.8341 | 0.7281 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5911.066 | 0.9168 | 0.8648 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5911.066 | 0.9000 | 0.8372 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5911.066 | 0.8621 | 0.7747 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5911.066 | 0.8696 | 0.7871 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5911.066 | 0.3913 | -0.0608 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5912.066 | 1.0318 | 1.0607 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5912.066 | 1.0246 | 1.0468 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5912.066 | 0.9614 | 0.9263 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5912.066 | 0.9996 | 0.9992 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5912.066 | 1.0223 | 1.0426 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5912.066 | 0.9794 | 0.9607 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5912.066 | 0.9882 | 0.9774 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5912.066 | 0.9601 | 0.9239 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5912.066 | 0.7257 | 0.4730 | 1.0480 |