Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7490.066 | 0.9326 | 0.9446 | 2.4829 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7490.066 | 0.9606 | 0.9678 | 2.4829 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7490.066 | 0.9377 | 0.9488 | 2.4829 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7490.066 | 0.9828 | 0.9861 | 2.4829 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7490.066 | 0.6724 | 0.7046 | 2.4829 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7490.066 | 0.4242 | 0.4159 | 2.4829 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7492.066 | 1.0616 | 1.0731 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7492.066 | 0.8953 | 0.8715 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7492.066 | 0.9362 | 0.9224 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7492.066 | 0.9787 | 0.9743 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7492.066 | 0.9283 | 0.9126 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7492.066 | 0.9753 | 0.9702 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7492.066 | 0.9375 | 0.9240 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7492.066 | 0.8735 | 0.8441 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7492.066 | 0.6627 | 0.5623 | 1.6656 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7493.066 | 0.9870 | 0.9805 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7493.066 | 1.0173 | 1.0260 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7493.066 | 1.0020 | 1.0031 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7493.066 | 1.0484 | 1.0724 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7493.066 | 1.0506 | 1.0756 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7493.066 | 0.9945 | 0.9917 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7493.066 | 1.0051 | 1.0076 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7493.066 | 0.9707 | 0.9557 | 1.3293 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7493.066 | 0.9833 | 0.9748 | 1.3293 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7494.066 | 0.9346 | 0.8613 | 0.9416 |