Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.267 | uM | 7486.066 | 0.9948 | 0.9901 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 1.33 | uM | 7486.066 | 1.0167 | 1.0321 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 6.67 | uM | 7486.066 | 0.6685 | 0.3601 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 33.3 | uM | 7486.066 | 0.3431 | -0.2819 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7487.066 | 0.9655 | 0.9561 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.000427 | uM | 7487.066 | 1.0052 | 1.0065 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.00213 | uM | 7487.066 | 0.9290 | 0.9092 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.0107 | uM | 7487.066 | 0.9842 | 0.9800 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.0533 | uM | 7487.066 | 0.9781 | 0.9722 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.267 | uM | 7487.066 | 0.9253 | 0.9044 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 1.33 | uM | 7487.066 | 0.9513 | 0.9379 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 6.67 | uM | 7487.066 | 0.3091 | -0.0468 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 33.3 | uM | 7487.066 | 0.2268 | -0.2159 | 1.5845 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7489.066 | 1.0524 | 1.0447 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7489.066 | 1.0307 | 1.0263 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7489.066 | 0.9682 | 0.9723 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7489.066 | 1.0053 | 1.0046 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7489.066 | 1.0289 | 1.0248 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7489.066 | 0.9584 | 0.9636 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7489.066 | 0.9064 | 0.9168 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7489.066 | 0.4674 | 0.4394 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7489.066 | 0.3079 | 0.2017 | 2.3124 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7490.066 | 0.9861 | 0.9888 | 2.4829 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7490.066 | 0.9522 | 0.9610 | 2.4829 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7490.066 | 1.0073 | 1.0059 | 2.4829 |