Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.267 | uM | 10469.066 | 0.9259 | 0.9077 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 10469.066 | 1.0006 | 1.0008 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 10469.066 | 0.8477 | 0.8072 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 33.3 | uM | 10469.066 | 0.8455 | 0.8043 | 1.6299 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7458.066 | 1.0651 | 1.3690 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7458.066 | 0.9692 | 0.8387 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7458.066 | 1.0595 | 1.3358 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7458.066 | 0.9949 | 0.9725 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7458.066 | 1.0080 | 1.0435 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7458.066 | 0.9396 | 0.6916 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7458.066 | 1.0068 | 1.0366 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7458.066 | 0.9445 | 0.7155 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7458.066 | 0.8865 | 0.4470 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10470.066 | 0.9812 | 0.9210 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 10470.066 | 0.9743 | 0.8926 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 10470.066 | 1.0248 | 1.1069 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 10470.066 | 1.0135 | 1.0577 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 10470.066 | 1.0001 | 1.0003 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 10470.066 | 1.0132 | 1.0564 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 10470.066 | 0.9819 | 0.9240 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 10470.066 | 0.9050 | 0.6183 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 10470.066 | 0.8404 | 0.3828 | 0.4712 | |
| HCC2185 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7462.066 | 1.0220 | 1.0786 | 0.5644 | |
| HCC2185 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7462.066 | 0.9712 | 0.8989 | 0.5644 | |
| HCC2185 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7462.066 | 0.9581 | 0.8540 | 0.5644 |