Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7453.084 | 0.9614 | 0.9502 | 1.5592 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7456.084 | 1.0269 | 1.0269 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7456.084 | 0.9754 | 0.9750 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7456.084 | 0.2612 | 0.0160 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7456.084 | 0.2756 | 0.0439 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7456.084 | 0.2867 | 0.0650 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7456.084 | 0.3037 | 0.0962 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7456.084 | 0.2854 | 0.0624 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7456.084 | 0.2828 | 0.0575 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7456.084 | 0.2922 | 0.0751 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7457.084 | 0.9772 | 0.9752 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7457.084 | 0.8653 | 0.8497 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7457.084 | 0.5245 | 0.4116 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7457.084 | 0.6060 | 0.5261 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7457.084 | 0.6167 | 0.5406 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7457.084 | 0.6928 | 0.6405 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7457.084 | 0.5996 | 0.5174 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7457.084 | 0.6216 | 0.5472 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7457.084 | 0.5784 | 0.4882 | 1.8520 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7458.084 | 0.9794 | 0.9278 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7458.084 | 1.0240 | 1.0856 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7458.084 | 0.8276 | 0.4310 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7458.084 | 0.7996 | 0.3465 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7458.084 | 0.7905 | 0.3195 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7458.084 | 0.8260 | 0.4260 | 0.5653 |