Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7458.084 | 0.8175 | 0.4003 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7458.084 | 0.8062 | 0.3662 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7458.084 | 0.8262 | 0.4266 | 0.5653 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7462.085 | 1.0162 | 1.0845 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7462.085 | 0.9657 | 0.8284 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7462.085 | 1.0198 | 1.1030 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7462.085 | 0.9870 | 0.9340 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7462.085 | 1.0122 | 1.0633 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7462.085 | 0.9884 | 0.9408 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7462.085 | 1.0052 | 1.0267 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7462.085 | 0.9902 | 0.9501 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7462.085 | 1.0037 | 1.0191 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7463.084 | 1.0368 | 1.0980 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7463.084 | 0.9173 | 0.7841 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7463.084 | 0.9976 | 0.9936 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7463.084 | 1.0278 | 1.0738 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7463.084 | 0.9449 | 0.8555 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7463.084 | 1.0431 | 1.1149 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7463.084 | 0.9952 | 0.9874 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7463.084 | 0.9597 | 0.8941 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7463.084 | 0.9719 | 0.9259 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7464.084 | 1.0186 | 1.0457 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7464.084 | 0.9843 | 0.9616 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7464.084 | 0.9650 | 0.9144 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7464.084 | 1.0571 | 1.1411 | 0.8152 |