Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7451.085 | 0.9024 | 0.9065 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7451.085 | 0.2969 | 0.1357 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7451.085 | 0.2875 | 0.1187 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7451.085 | 0.3011 | 0.1431 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7451.085 | 0.2965 | 0.1350 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7451.085 | 0.2902 | 0.1236 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7451.085 | 0.3029 | 0.1463 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7451.085 | 0.3496 | 0.2255 | 2.1458 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7452.084 | 0.9518 | 0.9421 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7452.084 | 1.0201 | 1.0239 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7452.084 | 0.9904 | 0.9886 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7452.084 | 1.0085 | 1.0101 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7452.084 | 1.0136 | 1.0162 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7452.084 | 0.9821 | 0.9786 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7452.084 | 1.0100 | 1.0119 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7452.084 | 1.0228 | 1.0270 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7452.084 | 0.9733 | 0.9680 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7453.084 | 1.0056 | 1.0072 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7453.084 | 0.9838 | 0.9791 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7453.084 | 1.0122 | 1.0156 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7453.084 | 0.9929 | 0.9909 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7453.084 | 1.0338 | 1.0430 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7453.084 | 1.0189 | 1.0242 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7453.084 | 0.9666 | 0.9569 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7453.084 | 0.9717 | 0.9636 | 1.5592 |