Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 9760.131 | 0.7443 | 0.4833 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 9760.131 | 0.7341 | 0.4626 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 9760.131 | 0.7697 | 0.5344 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 9760.131 | 0.6929 | 0.3795 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 9760.131 | 0.7349 | 0.4643 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 9760.131 | 0.3757 | -0.2577 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 9760.131 | 0.2675 | -0.4736 | 0.9878 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 0.0492 | uM | 9797.017 | 0.9488 | 0.7936 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 0.246 | uM | 9797.017 | 0.9857 | 0.9413 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 1.23 | uM | 9797.017 | 0.9205 | 0.6845 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 6.15 | uM | 9797.017 | 0.9972 | 0.9886 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 30.7 | uM | 9797.017 | 1.0556 | 1.2372 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 154 | uM | 9797.017 | 0.8889 | 0.5667 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 769 | uM | 9797.017 | 0.7920 | 0.2334 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 3840 | uM | 9797.017 | 0.5293 | -0.4652 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 19200 | uM | 9797.017 | 0.3428 | -0.7827 | 0.4824 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 0.0492 | uM | 7917.13 | 1.0520 | 1.0370 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 0.246 | uM | 7917.13 | 1.1361 | 1.0945 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 1.23 | uM | 7917.13 | 0.9827 | 0.9874 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 6.15 | uM | 7917.13 | 0.8832 | 0.9121 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 30.7 | uM | 7917.13 | 0.6494 | 0.7109 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 154 | uM | 7917.13 | 0.4782 | 0.5316 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 769 | uM | 7917.13 | 0.2444 | 0.2014 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 3840 | uM | 7917.13 | 0.0727 | -0.2252 | 2.7649 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 19200 | uM | 7917.13 | 0.0169 | -0.5424 | 2.7649 |