Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 5905.088 | 1.0093 | 1.0192 | 0.9646 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 5905.088 | 1.0138 | 1.0286 | 0.9646 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 5905.088 | 0.9815 | 0.9617 | 0.9646 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 5905.088 | 1.0116 | 1.0240 | 0.9646 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 5905.088 | 0.9803 | 0.9592 | 0.9646 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 5905.088 | 1.0108 | 1.0225 | 0.9646 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 5905.088 | 0.9973 | 0.9944 | 0.9646 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 5905.088 | 0.9143 | 0.8225 | 0.9646 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 5909.088 | 1.0566 | 1.0375 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 5909.088 | 1.0382 | 1.0254 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 5909.088 | 1.0198 | 1.0132 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 5909.088 | 1.0214 | 1.0144 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 5909.088 | 1.0249 | 1.0167 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 5909.088 | 1.0046 | 1.0031 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 5909.088 | 1.0565 | 1.0374 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 5909.088 | 1.1088 | 1.0709 | 2.9659 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 5909.088 | 1.1441 | 1.0928 | 2.9659 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7430.088 | 1.0244 | 1.0263 | 1.8441 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7430.088 | 0.9987 | 0.9986 | 1.8441 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7430.088 | 0.9891 | 0.9882 | 1.8441 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7430.088 | 0.9608 | 0.9571 | 1.8441 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7430.088 | 1.0447 | 1.0480 | 1.8441 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.267 | uM | 7430.088 | 0.9900 | 0.9891 | 1.8441 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 1.33 | uM | 7430.088 | 1.0309 | 1.0333 | 1.8441 | |
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 6.67 | uM | 7430.088 | 0.9750 | 0.9727 | 1.8441 |