Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10139.001 | 0.9519 | 0.8700 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10139.001 | 0.5425 | -0.1311 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10139.001 | 0.4231 | -0.3808 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10139.001 | 0.4776 | -0.2696 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10139.001 | 0.5234 | -0.1726 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10139.001 | 0.5040 | -0.2141 | 0.7336 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7917.001 | 0.9547 | 0.9688 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7917.001 | 0.9408 | 0.9590 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7917.001 | 1.0264 | 1.0178 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7917.001 | 0.9065 | 0.9345 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7917.001 | 0.6147 | 0.6957 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7917.001 | 0.3688 | 0.4260 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7917.001 | 0.3745 | 0.4334 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7917.001 | 0.4242 | 0.4953 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7917.001 | 0.0817 | -0.1446 | 2.9486 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9830.001 | 1.0115 | 1.0112 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9830.001 | 1.0297 | 1.0290 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9830.001 | 0.9941 | 0.9942 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9830.001 | 1.0011 | 1.0011 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9830.001 | 0.6980 | 0.6761 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9830.001 | 0.3684 | 0.2243 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9830.001 | 0.5374 | 0.4740 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9830.001 | 0.6528 | 0.6218 | 2.0346 | |
| SUM149PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9830.001 | 0.2370 | -0.0143 | 2.0346 | |
| SUM159PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7918.001 | 1.1657 | 1.1093 | 2.8818 |