Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10127.001 | 0.3668 | -0.3796 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10127.001 | 0.3953 | -0.3230 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10127.001 | 0.4432 | -0.2264 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10127.001 | 0.1329 | -0.8103 | 0.8568 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9777.001 | 1.0521 | 1.1457 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9777.001 | 1.2795 | 1.8132 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9777.001 | 0.9728 | 0.9251 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9777.001 | 1.0355 | 1.0990 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9777.001 | 1.2160 | 1.6219 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9777.001 | 1.0899 | 1.2531 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9777.001 | 1.1027 | 1.2899 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9777.001 | 0.7855 | 0.4318 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9777.001 | 0.2689 | -0.6754 | 0.7223 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9797.001 | 1.0326 | 1.1097 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9797.001 | 1.0186 | 1.0624 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9797.001 | 0.9607 | 0.8710 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9797.001 | 1.0072 | 1.0240 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9797.001 | 0.6814 | 0.0566 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9797.001 | 0.3412 | -0.6656 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9797.001 | 0.3849 | -0.5915 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9797.001 | 0.4298 | -0.5091 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9797.001 | 0.2966 | -0.7351 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10139.001 | 1.0181 | 1.0494 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10139.001 | 0.9506 | 0.8666 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10139.001 | 1.0076 | 1.0207 | 0.7336 |