Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 5897.088 | 1.0107 | 1.0165 | 1.2950 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 5897.088 | 0.9677 | 0.9499 | 1.2950 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 0.267 | uM | 5897.088 | 0.9341 | 0.8974 | 1.2950 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 1.33 | uM | 5897.088 | 0.9032 | 0.8488 | 1.2950 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 6.67 | uM | 5897.088 | 0.4094 | 0.0036 | 1.2950 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 33.3 | uM | 5897.088 | 0.3189 | -0.1725 | 1.2950 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 5898.088 | 1.0158 | 1.0521 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 5898.088 | 0.9401 | 0.8074 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 5898.088 | 0.9774 | 0.9264 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 5898.088 | 0.9806 | 0.9368 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 5898.088 | 1.0153 | 1.0503 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 5898.088 | 0.9743 | 0.9164 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 5898.088 | 1.0147 | 1.0486 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 5898.088 | 1.0458 | 1.1525 | 0.6095 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 5898.088 | 0.9428 | 0.8157 | 0.6095 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 5900.088 | 0.9832 | 0.9878 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 5900.088 | 1.0035 | 1.0025 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 5900.088 | 1.0066 | 1.0048 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 5900.088 | 0.9892 | 0.9922 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 5900.088 | 0.9895 | 0.9924 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 5900.088 | 0.9676 | 0.9764 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 5900.088 | 1.0283 | 1.0202 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 5900.088 | 0.8507 | 0.8871 | 2.7830 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 5900.088 | 0.5830 | 0.6475 | 2.7830 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 5905.088 | 1.0551 | 1.1143 | 0.9646 |