Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9972.001 | 0.5971 | 0.2251 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9972.001 | 0.6090 | 0.2483 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9972.001 | 0.6188 | 0.2673 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9972.001 | 0.4604 | -0.0433 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9997.001 | 1.0060 | 1.0120 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9997.001 | 1.0141 | 1.0282 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9997.001 | 1.0360 | 1.0719 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9997.001 | 0.9833 | 0.9666 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9997.001 | 0.7267 | 0.4535 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9997.001 | 0.6845 | 0.3691 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9997.001 | 0.6211 | 0.2423 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9997.001 | 0.6772 | 0.3546 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9997.001 | 0.5231 | 0.0463 | 1.0003 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 5895.088 | 1.1085 | 1.1611 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 5895.088 | 1.0447 | 1.0669 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 5895.088 | 1.0534 | 1.0797 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 5895.088 | 1.0605 | 1.0904 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 5895.088 | 1.0538 | 1.0804 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 0.267 | uM | 5895.088 | 0.9218 | 0.8812 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 1.33 | uM | 5895.088 | 0.8141 | 0.7134 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 6.67 | uM | 5895.088 | 0.3675 | -0.0580 | 1.3297 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 33.3 | uM | 5895.088 | 0.1434 | -0.5359 | 1.3297 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 5897.088 | 1.0420 | 1.0645 | 1.2950 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 5897.088 | 0.9738 | 0.9595 | 1.2950 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 5897.088 | 0.9726 | 0.9575 | 1.2950 |