Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7931.001 | 0.5929 | 0.3337 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7931.001 | 0.4907 | 0.1518 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7932.001 | 1.0159 | 1.0310 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7932.001 | 0.9286 | 0.8605 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7932.001 | 1.0755 | 1.1470 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7932.001 | 1.0030 | 1.0059 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7932.001 | 0.8361 | 0.6797 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7932.001 | 0.6611 | 0.3360 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7932.001 | 0.6051 | 0.2254 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7932.001 | 0.6580 | 0.3299 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7932.001 | 0.6153 | 0.2457 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9958.001 | 0.9949 | 0.9804 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9958.001 | 0.9831 | 0.9351 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9958.001 | 0.9950 | 0.9806 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9958.001 | 0.9988 | 0.9955 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9958.001 | 0.6680 | -0.0844 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9958.001 | 0.6493 | -0.1333 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9958.001 | 0.6565 | -0.1146 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9958.001 | 0.6548 | -0.1192 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9958.001 | 0.4966 | -0.4843 | 0.5164 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9972.001 | 1.0037 | 1.0071 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9972.001 | 0.9994 | 0.9988 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9972.001 | 1.0157 | 1.0298 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9972.001 | 0.9635 | 0.9305 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9972.001 | 0.8211 | 0.6583 | 1.0521 |