Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10263.001 | 0.4440 | -0.8345 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10263.001 | 0.4810 | -0.7884 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10263.001 | 0.6295 | -0.5167 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10263.001 | 0.6244 | -0.5287 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10263.001 | 0.2343 | -0.9767 | 0.3258 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7853.001 | 0.9866 | 0.9830 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7853.001 | 0.9875 | 0.9841 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7853.001 | 0.9739 | 0.9667 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7853.001 | 0.9142 | 0.8894 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7853.001 | 0.3462 | 0.0210 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7853.001 | 0.3526 | 0.0330 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7853.001 | 0.4214 | 0.1564 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7853.001 | 0.4146 | 0.1446 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7853.001 | 0.3006 | -0.0665 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10056.001 | 0.9916 | 0.9815 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10056.001 | 0.9946 | 0.9882 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10056.001 | 1.0035 | 1.0077 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10056.001 | 0.9323 | 0.8510 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10056.001 | 0.5024 | -0.0652 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 10056.001 | 0.5015 | -0.0668 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 10056.001 | 0.5770 | 0.0895 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 10056.001 | 0.5897 | 0.1159 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 10056.001 | 0.3357 | -0.4012 | 0.9052 | |
| HCC38 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9453.001 | 0.9784 | 0.9657 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9453.001 | 1.0176 | 1.0279 | 1.2616 |