Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7812.001 | 0.3671 | -0.2615 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7812.001 | 0.4480 | -0.0998 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7812.001 | 0.6131 | 0.2298 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9244.001 | 1.0548 | 1.2068 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9244.001 | 1.1387 | 1.5417 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9244.001 | 1.0749 | 1.2852 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9244.001 | 0.9179 | 0.7077 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9244.001 | 0.0681 | -0.9859 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 9244.001 | 0.1768 | -0.9182 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 9244.001 | 0.3720 | -0.6773 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 9244.001 | 0.5334 | -0.3726 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 9244.001 | 0.2155 | -0.8821 | 0.5421 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7813.001 | 1.0713 | 1.1968 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7813.001 | 1.2015 | 1.5685 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7813.001 | 1.2430 | 1.6901 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7813.001 | 0.8014 | 0.4791 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7813.001 | 0.3620 | -0.4993 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7813.001 | 0.4151 | -0.3966 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7813.001 | 0.4107 | -0.4052 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7813.001 | 0.4107 | -0.4052 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7813.001 | 0.0022 | -0.9995 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7816.001 | 1.0183 | 1.0358 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7816.001 | 1.0172 | 1.0335 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7816.001 | 0.4475 | -0.0877 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7816.001 | 0.3189 | -0.3447 | 1.0243 |