Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7816.001 | 0.3223 | -0.3380 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7816.001 | 0.3472 | -0.2880 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7816.001 | 0.2994 | -0.3839 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7816.001 | 0.2576 | -0.4681 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7816.001 | 0.0087 | -0.9805 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9254.001 | 1.0766 | 1.4071 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9254.001 | 0.9083 | 0.5711 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9254.001 | 1.1786 | 2.0208 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9254.001 | 0.5611 | -0.5308 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9254.001 | 0.5575 | -0.5383 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 9254.001 | 0.6477 | -0.3274 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 9254.001 | 0.6448 | -0.3350 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 9254.001 | 0.5802 | -0.4898 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 9254.001 | 0.0010 | -1.0000 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9258.001 | 0.9986 | 0.9960 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9258.001 | 0.9961 | 0.9890 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9258.001 | 0.9186 | 0.7757 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9258.001 | 0.7311 | 0.2895 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9258.001 | 0.4004 | -0.4452 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 9258.001 | 0.3165 | -0.6010 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 9258.001 | 0.3036 | -0.6236 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 9258.001 | 0.2526 | -0.7091 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 9258.001 | 0.0005 | -1.0000 | 0.7137 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7819.001 | 1.0026 | 1.0105 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7819.001 | 1.0253 | 1.1043 | 0.4919 |