Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12003.143 | 0.8585 | 0.7702 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12003.143 | 0.9864 | 0.9782 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12003.143 | 0.6704 | 0.4524 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 12003.143 | 0.5890 | 0.3094 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 12003.143 | 0.5727 | 0.2803 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 12003.143 | 0.5130 | 0.1724 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 12003.143 | 0.4825 | 0.1163 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 12003.143 | 0.3617 | -0.1135 | 1.2499 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11939.143 | 0.9547 | 0.9474 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11939.143 | 0.9755 | 0.9717 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 11939.143 | 0.9918 | 0.9905 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11939.143 | 0.7851 | 0.7405 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 11939.143 | 0.6063 | 0.5004 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 11939.143 | 0.4680 | 0.2932 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 11939.143 | 0.4236 | 0.2213 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 11939.143 | 0.3653 | 0.1217 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 11939.143 | 0.3176 | 0.0351 | 1.7414 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 0.0492 | uM | 9047.017 | 0.9725 | 0.9350 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 0.246 | uM | 9047.017 | 0.9547 | 0.8932 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 1.23 | uM | 9047.017 | 1.0292 | 1.0694 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 6.15 | uM | 9047.017 | 0.8400 | 0.6268 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 30.7 | uM | 9047.017 | 0.9094 | 0.7871 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 154 | uM | 9047.017 | 0.4338 | -0.2566 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 769 | uM | 9047.017 | 0.1559 | -0.7788 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 3840 | uM | 9047.017 | 0.1150 | -0.8459 | 0.8440 |