Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9664.001 | 0.9098 | 0.7769 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9664.001 | 0.8050 | 0.5247 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9664.001 | 0.7850 | 0.4776 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9664.001 | 0.8191 | 0.5581 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9664.001 | 0.5900 | 0.0337 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9664.001 | 0.0610 | -0.9395 | 0.7994 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7898.001 | 1.1222 | 1.1959 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7898.001 | 0.8300 | 0.7196 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7898.001 | 1.0433 | 1.0700 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7898.001 | 0.9306 | 0.8867 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7898.001 | 0.7534 | 0.5897 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7898.001 | 0.4988 | 0.1380 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7898.001 | 0.5204 | 0.1779 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7898.001 | 0.3806 | -0.0859 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7898.001 | 0.1993 | -0.4589 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7899.001 | 1.1127 | 1.1073 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7899.001 | 0.9129 | 0.9128 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7899.001 | 1.1102 | 1.1049 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7899.001 | 0.9444 | 0.9448 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7899.001 | 0.8775 | 0.8761 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7899.001 | 0.4865 | 0.4059 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7899.001 | 0.4820 | 0.3996 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7899.001 | 0.5194 | 0.4517 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7899.001 | 0.2246 | -0.0366 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7900.001 | 1.3847 | 2.0128 | 0.7944 |