Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7808.011 | 0.0646 | -0.3521 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7808.011 | 0.0700 | -0.3304 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7808.011 | 0.0540 | -0.3982 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7808.011 | 0.0354 | -0.4944 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7808.011 | 0.0599 | -0.3721 | 2.4301 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7810.011 | 1.0547 | 1.1187 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7810.011 | 1.1608 | 1.3500 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7810.011 | 0.6203 | 0.1930 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7810.011 | 0.5661 | 0.0806 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7810.011 | 0.5737 | 0.0963 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7810.011 | 0.4899 | -0.0758 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7810.011 | 0.4955 | -0.0645 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7810.011 | 0.4759 | -0.1045 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7810.011 | 0.4955 | -0.0645 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.000168 | uM | 9233.12 | 1.0887 | 1.1543 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00084 | uM | 9233.12 | 0.9684 | 0.9447 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.0042 | uM | 9233.12 | 1.0618 | 1.1077 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.021 | uM | 9233.12 | 0.5066 | 0.1038 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.105 | uM | 9233.12 | 0.5062 | 0.1031 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.525 | uM | 9233.12 | 0.4632 | 0.0208 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 2.62 | uM | 9233.12 | 0.3939 | -0.1140 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 13.1 | uM | 9233.12 | 0.3926 | -0.1166 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 65.6 | uM | 9233.12 | 0.3733 | -0.1546 | 1.1442 | |
| HCC1187 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7811.011 | 0.9600 | 0.8226 | 0.4400 | |
| HCC1187 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7811.011 | 0.9516 | 0.7869 | 0.4400 |