Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9760.024 | 0.4278 | -0.1276 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9760.024 | 0.3880 | -0.2070 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10127.049 | 1.0905 | 1.2952 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10127.049 | 1.0475 | 1.1529 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10127.049 | 0.9538 | 0.8553 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10127.049 | 0.8844 | 0.6452 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10127.049 | 0.6873 | 0.1023 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10127.049 | 0.6110 | -0.0858 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10127.049 | 0.6310 | -0.0376 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10127.049 | 0.8643 | 0.5863 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10127.049 | 0.7946 | 0.3881 | 0.6294 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9777.049 | 0.8595 | 0.5699 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9777.049 | 0.7561 | 0.2790 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9777.049 | 1.0008 | 1.0026 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9777.049 | 0.5388 | -0.2560 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9777.049 | 0.5347 | -0.2649 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9777.049 | 0.4717 | -0.3984 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9777.049 | 0.1923 | -0.8568 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9777.049 | 0.3805 | -0.5734 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9777.049 | 0.2439 | -0.7904 | 0.6254 | |
| SUM1315MO2 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9797.012 | 0.9993 | 0.9971 | 0.4792 | |
| SUM1315MO2 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9797.012 | 1.0272 | 1.1153 | 0.4792 | |
| SUM1315MO2 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9797.012 | 0.8095 | 0.2868 | 0.4792 | |
| SUM1315MO2 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9797.012 | 0.6147 | -0.2757 | 0.4792 | |
| SUM1315MO2 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9797.012 | 0.4557 | -0.6122 | 0.4792 |