Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7907.012 | 0.9493 | 0.9264 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7907.012 | 1.1992 | 1.2798 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7907.012 | 0.9026 | 0.8576 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7907.012 | 0.6332 | 0.4387 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7907.012 | 0.1522 | -0.4851 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7907.012 | 0.1506 | -0.4892 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7907.012 | 0.1739 | -0.4332 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7907.012 | 0.1734 | -0.4344 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7907.012 | 0.1985 | -0.3766 | 1.3872 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9759.012 | 0.9905 | 0.9860 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9759.012 | 1.0145 | 1.0213 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9759.012 | 0.8146 | 0.7200 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9759.012 | 0.4906 | 0.1844 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9759.012 | 0.4071 | 0.0325 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9759.012 | 0.3770 | -0.0242 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9759.012 | 0.3759 | -0.0264 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9759.012 | 0.2923 | -0.1909 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9759.012 | 0.3388 | -0.0981 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9760.024 | 0.9877 | 0.9760 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9760.024 | 1.0047 | 1.0093 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9760.024 | 0.9203 | 0.8440 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9760.024 | 0.5437 | 0.1026 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9760.024 | 0.4604 | -0.0627 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9760.024 | 0.4602 | -0.0631 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9760.024 | 0.4663 | -0.0511 | 1.0234 |