Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9723.049 | 1.0497 | 1.1045 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9723.049 | 1.0203 | 1.0427 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9723.049 | 0.2262 | -0.5799 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9723.049 | 0.2173 | -0.5974 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9723.049 | 0.2072 | -0.6170 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9723.049 | 0.2414 | -0.5503 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9723.049 | 0.2407 | -0.5517 | 0.9525 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7905.012 | 0.9417 | 0.8362 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7905.012 | 1.0804 | 1.2326 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7905.012 | 0.9183 | 0.7716 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7905.012 | 0.6401 | 0.0600 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7905.012 | 0.1312 | -0.8889 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7905.012 | 0.2082 | -0.7856 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7905.012 | 0.1926 | -0.8082 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7905.012 | 0.2392 | -0.7388 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7905.012 | 0.2537 | -0.7159 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7906.012 | 0.7773 | 0.1979 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7906.012 | 0.9727 | 0.8904 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7906.012 | 0.5438 | -0.4207 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7906.012 | 0.7185 | 0.0209 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7906.012 | 0.2205 | -0.9077 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7906.012 | 0.2120 | -0.9148 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7906.012 | 0.2662 | -0.8645 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7906.012 | 0.3149 | -0.8093 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7906.012 | 0.5913 | -0.3131 | 0.4916 |