Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7862.04 | 0.3931 | 0.0530 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7862.04 | 0.1523 | -0.4510 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7862.04 | 0.1880 | -0.3656 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7862.04 | 0.1423 | -0.4761 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7862.04 | 0.1271 | -0.5151 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9511.012 | 1.0069 | 1.0110 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9511.012 | 1.0318 | 1.0505 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9511.012 | 0.9943 | 0.9909 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9511.012 | 0.6221 | 0.3709 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9511.012 | 0.3742 | -0.0851 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9511.012 | 0.3222 | -0.1877 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9511.012 | 0.2615 | -0.3121 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9511.012 | 0.1490 | -0.5604 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9511.012 | 0.1878 | -0.4713 | 1.2568 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9536.012 | 1.0303 | 1.0427 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9536.012 | 1.0512 | 1.0722 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9536.012 | 1.0091 | 1.0129 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9536.012 | 0.9122 | 0.8738 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9536.012 | 0.5480 | 0.3053 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9536.012 | 0.3193 | -0.1103 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9536.012 | 0.2586 | -0.2339 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9536.012 | 0.2344 | -0.2853 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9536.012 | 0.2119 | -0.3348 | 1.4096 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10264.024 | 0.9590 | 0.9326 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10264.024 | 1.0850 | 1.1380 | 1.2223 |