Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9501.024 | 0.2525 | -0.5530 | 0.9185 | |
| HCC70 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9501.024 | 0.1879 | -0.6761 | 0.9185 | |
| HCC70 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9501.024 | 0.2030 | -0.6476 | 0.9185 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10124.012 | 1.3078 | 1.2940 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10124.012 | 0.8972 | 0.8921 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10124.012 | 0.3762 | 0.2134 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10124.012 | 0.3685 | 0.2006 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10124.012 | 0.2996 | 0.0802 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10124.012 | 0.3357 | 0.1448 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10124.012 | 0.3563 | 0.1802 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10124.012 | 0.2826 | 0.0483 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10124.012 | 0.3282 | 0.1316 | 1.9565 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10147.012 | 1.0639 | 1.0763 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10147.012 | 1.2102 | 1.2445 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10147.012 | 0.5523 | 0.3969 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10147.012 | 0.4178 | 0.1801 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10147.012 | 0.3367 | 0.0357 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10147.012 | 0.2017 | -0.2401 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10147.012 | 0.2319 | -0.1732 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10147.012 | 0.2220 | -0.1948 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10147.012 | 0.2116 | -0.2179 | 1.6544 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7862.04 | 0.9601 | 0.9449 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7862.04 | 0.8892 | 0.8449 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7862.04 | 1.0157 | 1.0216 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7862.04 | 0.9276 | 0.8994 | 1.4556 |