Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10264.024 | 0.9336 | 0.8906 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10264.024 | 0.7120 | 0.5147 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10264.024 | 0.3764 | -0.1008 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10264.024 | 0.3542 | -0.1444 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10264.024 | 0.3002 | -0.2528 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10264.024 | 0.3071 | -0.2388 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10264.024 | 0.3053 | -0.2424 | 1.2223 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7867.04 | 1.0442 | 1.0357 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7867.04 | 0.9798 | 0.9834 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7867.04 | 0.3804 | 0.3472 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7867.04 | 0.0586 | -0.3729 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7867.04 | 0.0609 | -0.3628 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7867.04 | 0.0555 | -0.3866 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7867.04 | 0.0553 | -0.3874 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7867.04 | 0.0462 | -0.4311 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7867.04 | 0.0454 | -0.4350 | 2.4460 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7870.012 | 1.0088 | 1.0076 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7870.012 | 0.9668 | 0.9710 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7870.012 | 0.5533 | 0.5482 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7870.012 | 0.1047 | -0.2467 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7870.012 | 0.1004 | -0.2602 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7870.012 | 0.0934 | -0.2830 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7870.012 | 0.0975 | -0.2696 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7870.012 | 0.0959 | -0.2748 | 2.3112 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7870.012 | 0.0933 | -0.2834 | 2.3112 |