Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10266.024 | 0.7453 | 0.2752 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10266.024 | 0.6849 | 0.1204 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10266.024 | 0.6742 | 0.0938 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10266.024 | 0.6820 | 0.1133 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10266.024 | 0.5110 | -0.2843 | 0.6533 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7903.04 | 1.0066 | 1.0109 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7903.04 | 0.9738 | 0.9565 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7903.04 | 1.0265 | 1.0437 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7903.04 | 0.1710 | -0.5364 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7903.04 | 0.2023 | -0.4674 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7903.04 | 0.1972 | -0.4783 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7903.04 | 0.1950 | -0.4832 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7903.04 | 0.2261 | -0.4160 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7903.04 | 0.1967 | -0.4794 | 1.2080 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9708.012 | 0.8971 | 0.7901 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9708.012 | 1.0835 | 1.1706 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9708.012 | 0.8035 | 0.5999 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9708.012 | 0.2366 | -0.5406 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9708.012 | 0.2704 | -0.4735 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9708.012 | 0.2662 | -0.4819 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9708.012 | 0.2596 | -0.4951 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9708.012 | 0.2292 | -0.5552 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9708.012 | 0.2349 | -0.5439 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9723.049 | 1.0480 | 1.1009 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9723.049 | 1.2105 | 1.4442 | 0.9525 |