Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7810.012 | 1.0646 | 1.1394 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7810.012 | 1.0061 | 1.0131 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7810.012 | 0.9171 | 0.8224 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7810.012 | 0.4581 | -0.1362 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7810.012 | 0.4357 | -0.1815 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7810.012 | 0.4329 | -0.1872 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7810.012 | 0.3857 | -0.2822 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7810.012 | 0.4077 | -0.2379 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9233.049 | 1.0587 | 1.1074 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9233.049 | 1.1096 | 1.2000 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9233.049 | 1.0838 | 1.1530 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9233.049 | 1.0337 | 1.0617 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9233.049 | 0.4657 | -0.0072 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9233.049 | 0.3099 | -0.3166 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9233.049 | 0.3064 | -0.3237 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9233.049 | 0.3688 | -0.1985 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9233.049 | 0.3785 | -0.1790 | 1.0911 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7811.04 | 1.0418 | 1.2204 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7811.04 | 1.0401 | 1.2111 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7811.04 | 0.9794 | 0.8966 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7811.04 | 0.9928 | 0.9634 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7811.04 | 0.3826 | -0.8275 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7811.04 | 0.4384 | -0.7558 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7811.04 | 0.4639 | -0.7180 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7811.04 | 0.4876 | -0.6798 | 0.3921 |