Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7811.04 | 0.3629 | -0.8492 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7812.04 | 1.0049 | 1.0093 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7812.04 | 1.0907 | 1.1712 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7812.04 | 1.0341 | 1.0644 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7812.04 | 0.5422 | 0.1210 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7812.04 | 0.5673 | 0.1701 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7812.04 | 0.6064 | 0.2462 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7812.04 | 0.5715 | 0.1782 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7812.04 | 0.6728 | 0.3749 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7812.04 | 0.6149 | 0.2627 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9244.012 | 1.0495 | 1.2382 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9244.012 | 1.1168 | 1.5872 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9244.012 | 0.9905 | 0.9561 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9244.012 | 0.6683 | -0.2181 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9244.012 | 0.4150 | -0.7423 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9244.012 | 0.4176 | -0.7385 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9244.012 | 0.4657 | -0.6630 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9244.012 | 0.6988 | -0.1322 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9244.012 | 0.6031 | -0.3844 | 0.4292 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7813.012 | 0.9263 | 0.8594 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7813.012 | 0.8059 | 0.6282 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7813.012 | 0.8959 | 0.8012 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7813.012 | 0.5978 | 0.2248 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7813.012 | 0.6820 | 0.3887 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7813.012 | 0.5428 | 0.1173 | 1.0493 |