Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 9664.049 | 1.0083 | 1.0230 | 0.7193 | |
| MDA-MB-415 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 9664.049 | 0.5497 | -0.1295 | 0.7193 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7898.016 | 0.9804 | 0.9677 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7898.016 | 1.0827 | 1.1354 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7898.016 | 0.9689 | 0.9486 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7898.016 | 1.0882 | 1.1444 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7898.016 | 1.0826 | 1.1353 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.267 | uM | 7898.016 | 1.0343 | 1.0563 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 1.33 | uM | 7898.016 | 1.0412 | 1.0677 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 7898.016 | 1.0477 | 1.0783 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 33.3 | uM | 7898.016 | 0.7147 | 0.5161 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7902.016 | 0.8193 | 0.8008 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7902.016 | 1.2049 | 1.2061 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7902.016 | 0.8361 | 0.8202 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7902.016 | 0.9809 | 0.9798 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7902.016 | 1.0661 | 1.0685 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.267 | uM | 7902.016 | 0.8885 | 0.8793 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 1.33 | uM | 7902.016 | 0.9690 | 0.9671 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 7902.016 | 1.1623 | 1.1647 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 33.3 | uM | 7902.016 | 0.7275 | 0.6917 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 10266.024 | 1.1844 | 1.5914 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 10266.024 | 0.8887 | 0.6694 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 10266.024 | 1.1753 | 1.5611 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0107 | uM | 10266.024 | 0.8421 | 0.5375 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0533 | uM | 10266.024 | 1.0428 | 1.1325 | 0.6533 |