Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9386.132 | 0.8770 | 0.8221 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9386.132 | 0.9345 | 0.9061 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9386.132 | 0.8314 | 0.7543 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.267 | uM | 9386.132 | 0.9791 | 0.9702 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 1.33 | uM | 9386.132 | 0.8486 | 0.7799 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 6.67 | uM | 9386.132 | 1.0485 | 1.0684 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 33.3 | uM | 9386.132 | 0.8299 | 0.7520 | 1.4083 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7840.016 | 0.9701 | 0.8803 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7840.016 | 0.9103 | 0.6520 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7840.016 | 0.9561 | 0.8256 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7840.016 | 0.9752 | 0.9006 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7840.016 | 0.9155 | 0.6715 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7840.016 | 0.9020 | 0.6215 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7840.016 | 0.8072 | 0.2940 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7840.016 | 0.6433 | -0.1843 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7840.016 | 0.3143 | -0.8099 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7841.016 | 0.9945 | 0.9755 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7841.016 | 0.9997 | 0.9985 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7841.016 | 0.9678 | 0.8595 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7841.016 | 1.0911 | 1.4282 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7841.016 | 1.0101 | 1.0453 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7841.016 | 0.9876 | 0.9451 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7841.016 | 0.8296 | 0.3196 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7841.016 | 0.6548 | -0.2207 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7841.016 | 0.2172 | -0.9331 | 0.4493 |