Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
SK-BR-3 Omipalisib 3 156.25
inf
0.1651
 0.6731 0.6544 0.5391 0.8296
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6423
0.0146
0.1349
 -0.6601 -0.9017 0.4638 0.9668
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6253
SK-BR-3 Omipalisib 3 312.50
0.6803
0.2553
 0.3486 0.1049 0.2403 0.5887
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9361
0.0016
0.1292
 -0.4719 -0.9419 0.2413 0.9648
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9331
SK-BR-3 Omipalisib 3 625.00
0.0813
0.0124
 0.3198 0.2892 0.4597 0.5063
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.989
0.0028
0.0116
 -0.4143 -0.4732 0.4685 1.0341
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9886
SK-BR-3 Omipalisib 3 1250.00
0.0411
0.0082
 0.2870 0.2708 0.4856 0.4669
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9961
0.0024
0.0087
 -0.3960 -0.4277 0.4865 1.0387
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9962
SK-BR-3 Omipalisib 3 2500.00
0.0361
0.0083
 0.2729 0.2808 0.5628 0.4620
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9904
0.0018
0.0067
 -0.5795 -0.5607 0.5759 1.1977
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9913
SK-BR-3 Omipalisib 3 5000.00
0.0739
0.0119
 0.3330 0.3543 0.6743 0.5248
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9876
0.0016
0.0052
 -0.8015 -0.7529 0.7880 1.4337
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9932
SK-BR-3 Etoposide 3 156.25
inf
20.2679
 0.8402 0.6709 4.4438 1.0253
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6319
inf
inf
 -0.0194 -0.0194 0.0000 0.2032
flat fit: x = Einf
0.285
SK-BR-3 Etoposide 3 312.50
inf
0.2453
 0.5269 0.5853 5.0000 0.7892
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9281
0.2462
0.244
 -0.1117 0.0217 5.0000 0.5147
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9338
SK-BR-3 Etoposide 3 625.00
1.9039
0.6002
 0.3983 0.4052 1.4405 0.7771
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9742
0.4681
0.5985
 -0.2119 -0.2035 1.3900 0.4595
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9841
SK-BR-3 Etoposide 3 1250.00
0.6925
0.2657
 0.4225 0.4841 3.6001 0.7374
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9485
0.2699
0.2664
 -0.0969 0.0206 3.2348 0.4956
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9472
SK-BR-3 Etoposide 3 2500.00
0.8402
0.2658
 0.3905 0.4207 1.6000 0.7148
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893
0.2043
0.2569
 -0.2936 -0.2296 1.6488 0.6115
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9901
SK-BR-3 Etoposide 3 5000.00
0.9621
0.2469
 0.4221 0.4464 1.6413 0.7228
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9902
0.1376
0.2009
 -0.6045 -0.5467 1.9519 0.8205
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9936
SK-BR-3 Methotrexate 3 156.25
inf
inf
 1.0279 1.0279 0.0000 1.0421
flat fit: x = Einf
-0.6692
inf
inf
 1.0500 1.0500 0.0000 -0.0500
flat fit: x = Einf
-inf
SK-BR-3 Methotrexate 3 312.50
inf
inf
 1.0354 1.0354 0.0000 1.0101
flat fit: x = Einf
-0.1259
inf
inf
 1.0500 1.0500 0.0000 0.0126
flat fit: x = Einf
0.182
SK-BR-3 Methotrexate 3 625.00
inf
inf
 0.9928 0.9928 0.0000 1.0009
flat fit: x = Einf
-0.0021
inf
inf
 0.9819 0.9819 0.0000 0.0026
flat fit: x = Einf
-0.0033
SK-BR-3 Methotrexate 3 1250.00
inf
0.0881
 0.6883 0.7061 5.0000 0.8460
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9788
0.1313
0.0881
 0.3973 0.4321 5.0000 0.3036
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9885
SK-BR-3 Methotrexate 3 2500.00
inf
0.0868
 0.5679 0.5805 4.9958 0.7765
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9913
0.0873
0.0858
 0.0136 0.0407 4.9999 0.5209
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9966
SK-BR-3 Methotrexate 3 5000.00
inf
0.1021
 0.5253 0.5285 3.0607 0.7563
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9969
0.0696
0.0895
 -0.4954 -0.4926 2.7278 0.7990
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9984
SK-BR-3 NVP-TAE684 4 156.25
inf
1.9282
 0.6062 0.6057 4.9997 0.9341
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8347
1.5338
1.8488
 -0.7477 -0.7723 4.9999 0.4270
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8324
SK-BR-3 NVP-TAE684 4 312.50
inf
1.3308
 0.5954 0.5809 1.8178 0.9258
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9475
1.6898
1.9013
 -0.4004 -0.4016 5.0000 0.2383
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.995
SK-BR-3 NVP-TAE684 4 625.00
3.2779
2.2548
 0.4286 0.4230 5.0000 0.9347
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9673
1.9185
2.1662
 -0.4063 -0.4175 5.0000 0.2178
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9927
SK-BR-3 NVP-TAE684 4 1250.00
3.0404
2.3552
 0.3597 0.3592 4.9631 0.8829
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9357
2.1685
2.3664
 -0.2726 -0.2738 5.0000 0.2487
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9443
SK-BR-3 NVP-TAE684 4 2500.00
3.0483
1.9201
 0.4209 0.4203 3.9738 0.9046
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9772
1.7355
1.9018
 -0.2182 -0.2195 3.9766 0.2250
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9892
SK-BR-3 NVP-TAE684 4 5000.00
5.092
2.5216
 0.4599 0.4550 3.4272 0.9183
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9815
2.1397
2.4402
 -0.2791 -0.2887 3.4683 0.2132
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9902
SK-BR-3 PLX-4720 4 156.25
inf
inf
 0.9347 0.9347 0.0000 1.0201
flat fit: x = Einf
0.0447
inf
inf
 1.0500 1.0500 0.0000 0.0768
flat fit: x = Einf
0.0