Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MCF7 Taxol 10 1250.00
0.0056
0.0034
 0.2720 0.2927 1.7451 0.5451
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9937
0.0065
0.0045
 0.1932 0.2194 1.5490 0.4790
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9948
MCF7 Taxol 10 2500.00
0.0081
0.0045
 0.2922 0.2994 1.5351 0.5692
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9901
0.0077
0.0055
 0.1815 0.1903 1.4104 0.4795
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9924
MCF7 Taxol 10 5000.00
0.0339
0.0074
 0.4326 0.4553 1.5883 0.7019
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9795
0.0145
0.0092
 0.2260 0.2639 1.6699 0.3798
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9745
MCF7 Linsitinib 10 156.25
inf
4.6073
 0.5783 0.5861 1.6763 0.9643
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8895
9.0102
8.7921
 0.2434 0.0150 1.2390 0.0871
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9311
MCF7 Linsitinib 10 312.50
inf
0.9978
 0.5494 0.6247 5.0000 0.8949
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9384
1.3492
1.0201
 0.2482 0.3765 5.0000 0.1870
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.952
MCF7 Linsitinib 10 625.00
inf
1.9384
 0.4620 0.5028 2.4667 0.8985
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9655
2.4716
2.0393
 0.1174 0.1846 2.3974 0.1799
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9796
MCF7 Linsitinib 10 1250.00
inf
0.8281
 0.4811 0.5256 2.4434 0.8511
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.975
1.617
0.8858
 0.3072 0.3711 2.2518 0.1976
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9795
MCF7 Linsitinib 10 2500.00
inf
0.7745
 0.4612 0.5143 4.6751 0.8263
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9738
1.1554
0.7904
 0.3275 0.4031 4.3222 0.2129
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9748
MCF7 Linsitinib 10 5000.00
3.605
0.6041
 0.4371 0.4768 1.7175 0.8026
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9818
1.3906
0.6888
 0.2831 0.3360 1.5862 0.2420
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.983
MCF7 Omipalisib 10 156.25
0.1429
0.0605
 0.3009 0.3155 1.1591 0.6089
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9764
0.0559
0.0419
 0.1066 0.1755 1.5039 0.4970
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9554
MCF7 Omipalisib 10 312.50
0.0515
0.024
 0.2667 0.2826 1.0928 0.5066
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9841
0.0345
0.024
 0.1201 0.1443 0.9317 0.5852
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9886
MCF7 Omipalisib 10 625.00
0.0409
0.0175
 0.2396 0.2582 0.8543 0.4692
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9599
0.0335
0.0229
 0.1088 0.1217 0.7291 0.5992
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9661
MCF7 Omipalisib 10 1250.00
0.0606
0.0252
 0.2160 0.2237 0.6758 0.4840
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9919
0.0526
0.0387
 0.0873 0.0781 0.5507 0.5645
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9926
MCF7 Omipalisib 10 2500.00
0.1051
0.0269
 0.2578 0.2374 0.4719 0.5148
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9906
0.0623
0.0425
 0.1185 0.0754 0.4267 0.5475
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9793
MCF7 Omipalisib 10 5000.00
1.1188
0.3928
 0.3618 0.1370 0.3059 0.6300
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9862
0.2092
1.4404
 0.1009 -0.3817 0.2940 0.4846
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9783
MCF7 17-AAG 10 156.25
0.1139
0.0298
 0.3304 0.3883 1.1191 0.5910
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9545
0.0271
0.0326
 -0.2501 -0.1285 1.2421 0.7441
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9608
MCF7 17-AAG 10 312.50
0.0393
0.0158
 0.3760 0.3785 1.5563 0.5451
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9387
0.0155
0.0169
 -0.0692 -0.0691 1.4794 0.7783
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9457
MCF7 17-AAG 10 625.00
0.0417
0.0239
 0.3165 0.3579 2.2580 0.5624
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9889
0.0235
0.0253
 -0.1594 -0.0820 2.0443 0.7308
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.99
MCF7 17-AAG 10 1250.00
0.0267
0.0186
 0.2823 0.3066 2.6231 0.5055
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9939
0.0204
0.0204
 -0.0418 0.0038 2.5133 0.7013
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.994
MCF7 17-AAG 10 2500.00
0.0342
0.0234
 0.2663 0.2885 2.2834 0.5136
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9911
0.0278
0.027
 -0.0070 0.0277 1.9663 0.6485
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9912
MCF7 17-AAG 10 5000.00
0.0592
0.0364
 0.2723 0.2991 1.8725 0.5535
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9954
0.0449
0.0427
 -0.0043 0.0425 1.7504 0.5934
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.995
MCF7 Palbociclib 11 156.25
0.4037
0.1682
 0.3160 0.4830 3.8610 0.7019
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.891
0.2702
0.1918
 0.1390 0.4028 4.7839 0.3432
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8235
MCF7 Palbociclib 11 312.50
0.4304
0.1611
 0.3845 0.4359 2.0900 0.6928
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9885
0.3164
0.1613
 0.3162 0.3941 2.3025 0.3307
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9813
MCF7 Palbociclib 11 625.00
0.4031
0.1524
 0.3591 0.4087 1.7483 0.6614
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9718
0.3377
0.1721
 0.3299 0.4108 2.5579 0.3293
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9721
MCF7 Palbociclib 11 1250.00
0.4556
0.158
 0.3828 0.4099 1.6180 0.6825
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9874
0.4883
0.1834
 0.3711 0.4102 1.7533 0.3059
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9842