Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MCF 10A Etoposide 6 312.50
0.1652
0.1586
 0.0410 0.0443 2.2406 0.4756
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9966
0.2727
0.266
 0.0049 0.0238 1.9512 0.4788
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9976
MCF 10A Etoposide 6 625.00
0.1354
0.131
 0.0319 0.0268 1.6846 0.4312
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9936
0.2452
0.2505
 -0.0269 -0.0174 1.5977 0.5151
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9977
MCF 10A Etoposide 6 1250.00
0.1457
0.1361
 0.0494 0.0450 1.3806 0.4468
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9953
0.2734
0.2795
 -0.0192 -0.0143 1.2867 0.4992
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.998
MCF 10A Etoposide 6 2500.00
0.1735
0.1479
 0.1121 0.1056 1.4891 0.4857
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9919
0.2185
0.2213
 -0.0139 -0.0099 1.5833 0.5307
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9966
MCF 10A Etoposide 6 5000.00
0.2206
0.1538
 0.2239 0.2201 1.6088 0.5505
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9878
0.2573
0.1968
 0.1862 0.1911 1.7961 0.4425
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9929
MCF 10A Methotrexate 6 156.25
inf
inf
 1.0500 1.0500 0.0000 1.0340
flat fit: x = Einf
-0.4488
inf
inf
 1.0243 1.0243 0.0000 -0.0339
flat fit: x = Einf
-1.2436
MCF 10A Methotrexate 6 312.50
inf
0.0572
 0.7996 0.8159 5.0000 0.8950
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8457
inf
0.0594
 0.9036 0.9103 4.7990 0.0488
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7477
MCF 10A Methotrexate 6 625.00
0.0788
0.0631
 0.3391 0.3344 5.0000 0.6064
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9916
inf
0.0679
 0.5846 0.5807 5.0000 0.2459
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9895
MCF 10A Methotrexate 6 1250.00
0.0666
0.0592
 0.2241 0.2217 5.0000 0.5448
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9955
0.0839
0.0601
 0.4029 0.4056 5.0000 0.3483
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9973
MCF 10A Methotrexate 6 2500.00
0.0666
0.0588
 0.2291 0.2310 5.0000 0.5505
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9984
0.0698
0.0607
 0.2437 0.2519 5.0000 0.4371
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9987
MCF 10A Methotrexate 6 5000.00
0.0756
0.0627
 0.2823 0.2913 4.6674 0.5848
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9992
0.0837
0.0682
 0.2901 0.3039 4.5721 0.4026
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9991
MCF 10A Lapatinib 7 156.25
7.1195
7.1195
 0.1461 0.0000 5.0000 0.9902
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9696
8.4511
10.5275
 0.1273 -0.9998 5.0000 0.0111
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9729
MCF 10A Lapatinib 7 312.50
3.5327
3.5327
 0.0419 0.0000 2.8715 0.8358
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9179
5.0734
6.2781
 0.0273 -0.3108 2.2690 0.1143
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9771
MCF 10A Lapatinib 7 625.00
2.6228
2.6228
 0.0260 0.0000 1.9670 0.7992
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.919
5.388
10.5152
 0.0984 -0.8739 1.5117 0.1211
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9756
MCF 10A Lapatinib 7 1250.00
3.225
3.225
 0.0526 0.0000 2.2516 0.8685
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9845
5.6561
7.3278
 0.1637 -0.3069 1.8484 0.0880
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9969
MCF 10A Lapatinib 7 2500.00
3.036
2.9726
 0.0709 0.0256 2.4892 0.8689
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9954
4.405
4.5226
 0.1026 -0.0324 2.3863 0.1005
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9989
MCF 10A Lapatinib 7 5000.00
5.2986
5.2986
 0.2583 0.0000 1.4387 0.8839
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9798
10.2276
24.9248
 0.5071 -1.0000 1.2333 0.0631
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9934
MCF 10A Erlotinib 7 156.25
0.4205
0.3434
 0.1878 0.2698 3.8283 0.6683
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9723
0.5224
0.3865
 0.2156 0.3244 3.4722 0.2902
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9689
MCF 10A Erlotinib 7 312.50
0.2138
0.1939
 0.0670 0.0750 1.6655 0.5158
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9975
0.4479
0.3505
 0.1361 0.1548 1.5095 0.3846
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.997
MCF 10A Erlotinib 7 625.00
0.2581
0.2475
 0.0616 0.0591 3.0075 0.5239
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9997
0.4298
0.3478
 0.2670 0.2626 3.5183 0.3448
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9988
MCF 10A Erlotinib 7 1250.00
0.321
0.3077
 0.0833 0.0950 5.0000 0.5721
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9987
0.5287
0.406
 0.2632 0.2797 3.1044 0.3172
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9983
MCF 10A Erlotinib 7 2500.00
0.3422
0.3177
 0.0988 0.1088 3.3068 0.5819
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9989
0.4842
0.4049
 0.1993 0.2179 3.1995 0.3454
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9991
MCF 10A Erlotinib 7 5000.00
0.7318
0.3511
 0.3722 0.3846 1.9967 0.7021
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.992
inf
0.4124
 0.6300 0.6431 2.1719 0.1642
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9945
MCF 10A Linsitinib 7 156.25
3.1361
3.1361
 0.1594 0.0000 0.8068 0.7675
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8861
5.5258
16.6266
 0.1463 -0.5707 0.6912 0.1920
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9204
MCF 10A Linsitinib 7 312.50
0.5817
0.568
 0.1234 0.0080 0.6784 0.5608
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8705
1.9549
1.0579
 0.2713 0.2022 0.8437 0.2945
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9411