Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | PLX-4720 | 5 | 1250.00 | inf | inf | 0.9395 | 0.9395 | 0.0000 | 1.0394 | flat fit: x = Einf | -0.5282 | inf | inf | 0.9043 | 0.9043 | 0.0000 | -0.0382 | flat fit: x = Einf | 0.0754 |
| SK-BR-3 | PLX-4720 | 5 | 2500.00 | inf | inf | 0.9573 | 0.9573 | 0.0000 | 1.0139 | flat fit: x = Einf | 0.1362 | inf | inf | 0.9316 | 0.9316 | 0.0000 | -0.0102 | flat fit: x = Einf | 0.3402 |
| SK-BR-3 | PLX-4720 | 5 | 5000.00 | inf | inf | 0.9863 | 0.9863 | 0.0000 | 1.0142 | flat fit: x = Einf | -0.4715 | inf | inf | 0.9872 | 0.9872 | 0.0000 | -0.0129 | flat fit: x = Einf | -0.4592 |
| SK-BR-3 | Palbociclib | 5 | 156.25 | inf | inf | 0.9386 | 0.9386 | 0.0000 | 0.9647 | flat fit: x = Einf | 0.1524 | inf | inf | 0.9178 | 0.9178 | 0.0000 | 0.0606 | flat fit: x = Einf | 0.0733 |
| SK-BR-3 | Palbociclib | 5 | 312.50 | inf | inf | 0.8828 | 0.8828 | 0.0000 | 0.9177 | flat fit: x = Einf | 0.3471 | inf | inf | 0.7165 | 0.7165 | 0.0000 | 0.2530 | flat fit: x = Einf | 0.2619 |
| SK-BR-3 | Palbociclib | 5 | 625.00 | inf | 0.1706 | 0.6748 | 0.6797 | 0.5366 | 0.8303 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9133 | 4.014 | 0.1752 | 0.3984 | 0.4098 | 0.5469 | 0.3111 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9139 |
| SK-BR-3 | Palbociclib | 5 | 1250.00 | 92.1358 | 4.5118 | 0.5523 | 0.3199 | 0.3385 | 0.7943 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9163 | 2.8536 | 7.6583 | 0.2691 | -0.1938 | 0.3318 | 0.3264 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9122 |
| SK-BR-3 | Palbociclib | 5 | 2500.00 | inf | 2.6466 | 0.5934 | 0.4027 | 0.3209 | 0.7972 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.936 | 2.8259 | 3.4512 | 0.3172 | -0.0330 | 0.3193 | 0.3343 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9365 |
| SK-BR-3 | Palbociclib | 5 | 5000.00 | inf | 0.8121 | 0.6379 | 0.5565 | 0.4214 | 0.8207 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9818 | inf | 1.2029 | 0.6177 | 0.5142 | 0.4153 | 0.1816 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9815 |
| SK-BR-3 | Nilotinib | 5 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0456 | flat fit: x = Einf | -19.73 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0474 | flat fit: x = Einf | -61.3317 |
| SK-BR-3 | Nilotinib | 5 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0270 | flat fit: x = Einf | -0.3137 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0030 | flat fit: x = Einf | 0.1293 |
| SK-BR-3 | Nilotinib | 5 | 625.00 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0384 | flat fit: x = Einf | -6.3636 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0425 | flat fit: x = Einf | -9.2043 |
| SK-BR-3 | Nilotinib | 5 | 1250.00 | inf | 9.8365 | 0.7031 | 0.6943 | 5.0000 | 1.0139 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8645 | inf | 9.8937 | 0.5236 | 0.5093 | 5.0000 | 0.0031 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9396 |
| SK-BR-3 | Nilotinib | 5 | 2500.00 | inf | 6.9415 | 0.5363 | 0.5316 | 5.0000 | 0.9698 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9681 | 7.89 | 7.0175 | 0.2291 | 0.2217 | 5.0000 | 0.0654 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9839 |
| SK-BR-3 | Nilotinib | 5 | 5000.00 | inf | 5.8713 | 0.5392 | 0.5381 | 4.8101 | 0.9538 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9848 | 28.5495 | 6.0632 | 0.5013 | 0.4997 | 4.8047 | 0.0524 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9888 |
| SK-BR-3 | Taxol | 5 | 156.25 | inf | inf | 0.9993 | 0.9993 | 0.0000 | 1.0148 | flat fit: x = Einf | -0.2152 | inf | inf | 1.0097 | 1.0097 | 0.0000 | -0.0135 | flat fit: x = Einf | -0.128 |
| SK-BR-3 | Taxol | 5 | 312.50 | inf | 0.0055 | 0.8010 | 0.8190 | 4.9920 | 0.9083 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7207 | 0.0069 | 0.0052 | 0.3315 | 0.3804 | 4.9992 | 0.3613 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7502 |
| SK-BR-3 | Taxol | 5 | 625.00 | inf | 0.0027 | 0.6079 | 0.5922 | 5.0000 | 0.7251 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9688 | 0.0031 | 0.0027 | 0.2686 | 0.2398 | 5.0000 | 0.5184 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9767 |
| SK-BR-3 | Taxol | 5 | 1250.00 | 0.0065 | 0.0032 | 0.4676 | 0.4855 | 5.0000 | 0.6696 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9912 | 0.0035 | 0.0033 | 0.1162 | 0.1493 | 5.0000 | 0.5480 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9953 |
| SK-BR-3 | Taxol | 5 | 2500.00 | 0.0138 | 0.0036 | 0.4920 | 0.4970 | 3.8166 | 0.6711 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9886 | 0.004 | 0.0037 | 0.1336 | 0.1434 | 3.9384 | 0.5593 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9925 |
| SK-BR-3 | Taxol | 5 | 5000.00 | inf | 0.004 | 0.5452 | 0.5554 | 4.9996 | 0.7244 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9972 | inf | 0.0041 | 0.5021 | 0.5155 | 5.0000 | 0.2992 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9975 |
| SK-BR-3 | Omipalisib | 5 | 156.25 | inf | inf | 0.7706 | 0.7706 | 0.0000 | 0.9468 | flat fit: x = Einf | 0.1823 | inf | inf | 0.6617 | 0.6617 | 0.0000 | 0.0958 | flat fit: x = Einf | 0.3323 |
| SK-BR-3 | Omipalisib | 5 | 312.50 | inf | 0.1729 | 0.5995 | 0.6032 | 0.4864 | 0.8127 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7738 | 0.0557 | 0.1002 | -0.2440 | -0.1860 | 0.5388 | 0.6187 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7787 |
| SK-BR-3 | Omipalisib | 5 | 625.00 | 0.7576 | 0.0167 | 0.4079 | 0.3792 | 0.3724 | 0.5952 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9707 | 0.0084 | 0.0199 | -0.1178 | -0.1847 | 0.3648 | 0.7556 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9709 |
| SK-BR-3 | Omipalisib | 5 | 1250.00 | 0.0443 | 0.0068 | 0.3463 | 0.3959 | 0.8354 | 0.5209 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9779 | 0.0074 | 0.0077 | -0.1130 | -0.0182 | 0.8297 | 0.7946 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9748 |