Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

 Full screen view
Filter results: >>>>
Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
Hs 578T NVP-TAE684 1 1250.00
1.5883
1.2337
 0.2031 0.1298 1.1900 0.7863
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.995
0.9492
1.5549
 -0.2623 -0.4048 1.2018 0.3132
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9968
Hs 578T NVP-TAE684 1 2500.00
2.1554
1.6821
 0.2345 0.1142 1.0459 0.8022
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9988
0.6964
1.6711
 -0.5139 -0.7502 1.0470 0.3925
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9987
Hs 578T NVP-TAE684 1 5000.00
7.6201
7.62
 0.4454 0.0000 0.7540 0.8706
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9918
0.1197
0.5011
 -0.9558 -1.0000 0.7673 0.7468
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9655
Hs 578T PLX-4720 1 156.25
inf
14.7271
 0.6062 0.5206 4.9871 0.9920
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6475
16.8572
14.215
 0.3963 0.2868 4.9998 0.0291
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.652
Hs 578T PLX-4720 1 312.50
20.9105
20.9105
 0.5507 0.0000 5.0000 1.0211
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9191
18.8801
23.5195
 0.3808 -1.0000 5.0000 -0.0148
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9533
Hs 578T PLX-4720 1 625.00
17.3658
10.9385
 0.4761 0.4504 5.0000 0.9786
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9568
12.1566
11.3243
 0.1961 0.1493 5.0000 0.0438
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9753
Hs 578T PLX-4720 1 1250.00
inf
11.9064
 0.5652 0.5327 5.0000 1.0035
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9326
15.4212
12.1242
 0.3990 0.3498 5.0000 0.0071
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9606
Hs 578T PLX-4720 1 2500.00
inf
11.0447
 0.6562 0.6384 5.0000 1.0058
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9194
13.0414
11.1138
 0.3118 0.2753 5.0000 0.0144
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9678
Hs 578T PLX-4720 1 5000.00
inf
inf
 0.9530 0.9530 0.0000 1.0370
flat fit: x = Einf
-0.6757
22.4908
28.0152
 0.6846 -0.9994 5.0000 -0.0354
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8206
Hs 578T Palbociclib 1 156.25
inf
0.0662
 0.3969 0.5575 1.2115 0.6756
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5405
inf
inf
 -0.0732 -0.0732 0.0000 0.5996
flat fit: x = Einf
0.4289
Hs 578T Palbociclib 1 312.50
0.7622
0.1357
 0.3759 0.3913 0.8843 0.6542
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8949
0.1277
0.1401
 -0.0679 -0.0407 0.8442 0.5909
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8982
Hs 578T Palbociclib 1 625.00
0.4185
0.2511
 0.3866 0.4112 3.3842 0.6412
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7327
inf
inf
 1.0500 1.0500 0.0000 0.0492
flat fit: x = Einf
0.0418
Hs 578T Palbociclib 1 1250.00
inf
0.0638
 0.5191 0.5329 0.7067 0.7014
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9722
0.3411
0.0721
 0.3194 0.3515 0.7808 0.4084
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9738
Hs 578T Palbociclib 1 2500.00
inf
0.0731
 0.6214 0.6604 2.5262 0.7695
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8373
0.0835
0.0768
 0.1187 0.1705 5.0000 0.5807
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7794
Hs 578T Palbociclib 1 5000.00
61.5204
61.5204
 0.5552 0.0000 0.2971 0.8067
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.4881
inf
inf
 0.4563 0.4563 0.0000 0.9182
flat fit: x = Einf
0.1527
Hs 578T Nilotinib 1 156.25
inf
inf
 1.0500 1.0500 0.0000 1.0003
flat fit: x = Einf
-0.0049
inf
inf
 1.0500 1.0500 0.0000 0.0212
flat fit: x = Einf
0.0271
Hs 578T Nilotinib 1 312.50
inf
inf
 1.0500 1.0500 0.0000 1.0307
flat fit: x = Einf
-0.5467
inf
inf
 1.0500 1.0500 0.0000 -0.0265
flat fit: x = Einf
-0.295
Hs 578T Nilotinib 1 625.00
inf
inf
 0.8173 0.8173 0.0000 0.9957
flat fit: x = Einf
0.1516
inf
inf
 0.7597 0.7597 0.0000 0.0138
flat fit: x = Einf
0.2227
Hs 578T Nilotinib 1 1250.00
inf
5.0311
 0.6197 0.7619 4.8866 0.9952
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6454
inf
4.9892
 0.4830 0.6804 4.9511 0.0190
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6529
Hs 578T Nilotinib 1 2500.00
inf
4.7947
 0.6649 0.8196 4.9383 1.0005
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5008
inf
4.7053
 0.3378 0.6590 4.9941 0.0318
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.4865
Hs 578T Nilotinib 1 5000.00
inf
6.1649
 0.5249 0.5158 5.0000 0.9714
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9546
4.8079
5.9668
 -0.9120 -0.9720 5.0000 0.2356
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9929
Hs 578T Taxol 1 156.25
0.002
0.0011
 0.3023 0.3305 1.8003 0.4764
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9739
0.001
0.0013
 -0.2560 -0.2013 1.8257 0.9182
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9776
Hs 578T Taxol 1 312.50
0.0021
0.001
 0.2879 0.2719 1.0756 0.4331
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9644
0.0008
0.0012
 -0.2417 -0.2733 1.1184 0.9734
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9631
Hs 578T Taxol 1 625.00
0.0034
0.0013
 0.3242 0.3222 1.1095 0.4921
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9701
inf
inf
 1.0500 1.0500 0.0000 0.0330
flat fit: x = Einf
-0.0086
Hs 578T Taxol 1 1250.00
0.0096
0.0026
 0.4202 0.4012 1.2404 0.5886
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9756
0.0035
0.0027
 0.1684 0.1373 1.3002 0.5903
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9747