Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

 Full screen view
Filter results: >>>>
Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
BT-20 Lapatinib 9 625.00
5.5378
3.7343
 0.4344 0.4303 5.0000 0.9797
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9499
3.8752
3.7987
 0.0549 0.0474 5.0000 0.0585
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9805
BT-20 Lapatinib 9 1250.00
6.9952
4.8281
 0.3994 0.2864 2.2939 0.9642
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9604
4.4932
5.3451
 0.0197 -0.2302 2.1814 0.0761
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9838
BT-20 Lapatinib 9 2500.00
7.0566
5.2221
 0.4015 0.1923 1.6121 0.9399
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9766
4.4484
6.2272
 0.0866 -0.3472 1.5677 0.0941
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9852
BT-20 Lapatinib 9 5000.00
9.0186
5.019
 0.4786 0.2724 1.3426 0.9239
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9969
4.2969
5.7832
 0.1689 -0.2371 1.3063 0.1187
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9974
BT-20 Erlotinib 9 156.25
inf
inf
 0.8335 0.8335 0.0000 1.0225
flat fit: x = Einf
0.0694
inf
inf
 0.5642 0.5642 0.0000 0.0031
flat fit: x = Einf
0.3323
BT-20 Erlotinib 9 312.50
inf
inf
 0.9260 0.9260 0.0000 1.0369
flat fit: x = Einf
-0.8631
inf
inf
 0.8374 0.8374 0.0000 -0.0275
flat fit: x = Einf
-0.0199
BT-20 Erlotinib 9 625.00
inf
3.0429
 0.7739 0.8572 5.0000 0.9920
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.651
inf
3.0505
 0.6379 0.7709 5.0000 0.0269
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6959
BT-20 Erlotinib 9 1250.00
inf
4.7287
 0.6654 0.6369 2.0558 0.9578
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.932
13.0486
4.8364
 0.4794 0.4362 2.0745 0.0772
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9603
BT-20 Erlotinib 9 2500.00
38.6433
5.8291
 0.5511 0.3710 0.7162 0.8794
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9582
8.1005
9.2203
 0.3423 -0.0453 0.6705 0.1736
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9682
BT-20 Erlotinib 9 5000.00
45.295
3.1004
 0.5441 0.4322 0.7450 0.8620
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893
4.5968
3.77
 0.2801 0.0669 0.7248 0.2129
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9898
BT-20 Linsitinib 9 156.25
inf
9.6376
 0.5851 0.5741 5.0000 0.9842
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9496
9.3971
9.7131
 -0.0610 -0.0899 5.0000 0.0740
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9793
BT-20 Linsitinib 9 312.50
inf
13.1105
 0.5587 0.5053 5.0000 1.0143
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9197
12.7732
13.1686
 0.0369 -0.0823 4.9997 0.0188
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9808
BT-20 Linsitinib 9 625.00
19.5688
19.3354
 0.4870 0.0139 2.3449 0.9922
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9512
14.0057
23.0438
 0.1547 -0.9991 2.2052 0.0319
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9785
BT-20 Linsitinib 9 1250.00
21.3991
21.3991
 0.5278 0.0000 1.9340 0.9879
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.938
14.6782
26.5591
 0.2512 -1.0000 1.8526 0.0350
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.968
BT-20 Linsitinib 9 2500.00
21.774
21.7739
 0.5253 0.0000 1.5544 0.9625
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9667
14.7303
30.6387
 0.3024 -1.0000 1.5001 0.0562
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9798
BT-20 Linsitinib 9 5000.00
28.4875
28.4875
 0.6212 0.0000 1.4577 0.9636
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9836
17.2935
37.1528
 0.4121 -1.0000 1.4366 0.0546
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9858
BT-20 17-AAG 9 156.25
0.0296
0.0043
 0.4467 0.4941 2.2993 0.7664
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9659
0.0035
0.0042
 -0.3531 -0.2560 2.1658 0.6105
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9832
BT-20 17-AAG 9 312.50
0.0097
0.0051
 0.4411 0.4417 3.3301 0.7476
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9859
0.0045
0.005
 -0.2053 -0.2053 3.2287 0.5703
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9965
BT-20 17-AAG 9 625.00
0.0106
0.0082
 0.3352 0.3616 5.0000 0.7441
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9869
0.0081
0.0084
 -0.1326 -0.0809 5.0000 0.4438
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9934
BT-20 17-AAG 9 1250.00
0.0115
0.0092
 0.3208 0.3319 4.9987 0.7338
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9917
0.0091
0.0095
 -0.1300 -0.1080 4.9821 0.4449
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9966
BT-20 17-AAG 9 2500.00
0.0209
0.0143
 0.2887 0.3010 2.4212 0.7580
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9951
0.0144
0.0156
 -0.1249 -0.1022 2.3772 0.3743
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.997
BT-20 17-AAG 9 5000.00
0.0368
0.0238
 0.3080 0.3189 2.3291 0.7958
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9982
0.0229
0.0253
 -0.1507 -0.1309 2.2680 0.3306
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9983
Hs 578T NVP-TAE684 1 156.25
1.0896
0.9142
 0.1729 0.1917 2.7563 0.8065
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9877
0.7963
1.0035
 -0.4292 -0.3985 2.5336 0.3369
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9944
Hs 578T NVP-TAE684 1 312.50
1.2531
1.0161
 0.2010 0.2292 2.9262 0.8262
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9878
1.0023
1.2019
 -0.2678 -0.2491 2.2256 0.2714
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9922
Hs 578T NVP-TAE684 1 625.00
1.37
1.1653
 0.1572 0.1032 1.4286 0.7758
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9823
0.8213
1.3702
 -0.4361 -0.5406 1.4320 0.3659
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893