LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 962 | 194 | 10692 | 0.0181 | -0.3695 |
| MCF 10A | AT-7519 | 10 | uM | LJP6 | 72 | hr | 962 | 195 | 10692 | 0.0183 | -0.3686 |
| MCF 10A | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 962 | 200 | 10692 | 0.0187 | -0.3636 |
| BT-20 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1097 | 201 | 3673 | 0.0550 | -0.6219 |
| Hs 578T | AZD7762 | 10 | uM | LJP6 | 72 | hr | 658 | 203 | 3761 | 0.0542 | -0.3743 |
| MCF 10A | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 962 | 204 | 10692 | 0.0191 | -0.3608 |
| MDA-MB-231 | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 1235 | 205 | 4405 | 0.0467 | -0.6246 |
| MCF 10A | Canertinib | 10 | uM | LJP6 | 72 | hr | 962 | 208 | 10692 | 0.0195 | -0.3567 |
| Hs 578T | NVP-TAE684 | 10 | uM | LJP6 | 72 | hr | 658 | 210 | 3761 | 0.0561 | -0.3648 |
| BT-20 | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 1097 | 211 | 3846 | 0.0547 | -0.6012 |
| MCF 10A | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 962 | 211 | 10512 | 0.0201 | -0.3563 |
| MCF 10A | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 962 | 212 | 10692 | 0.0198 | -0.3536 |
| Hs 578T | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 658 | 212 | 3933 | 0.0539 | -0.3573 |
| Hs 578T | GSK1059615 | 10 | uM | LJP5 | 72 | hr | 658 | 223 | 3933 | 0.0568 | -0.3427 |
| MCF7 | JNK-9L | 10 | uM | LJP6 | 72 | hr | 1209 | 233 | 4012 | 0.0581 | -0.6146 |
| MDA-MB-231 | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 1235 | 234 | 4405 | 0.0524 | -0.6111 |
| Hs 578T | Celastrol | 10 | uM | LJP6 | 72 | hr | 658 | 235 | 3761 | 0.0625 | -0.3377 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 962 | 236 | 10692 | 0.0221 | -0.3323 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 962 | 238 | 10692 | 0.0223 | -0.3328 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 962 | 245 | 10512 | 0.0233 | -0.3280 |
| MCF 10A | Alvocidib | 10 | uM | LJP6 | 72 | hr | 962 | 252 | 10692 | 0.0236 | -0.3198 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 962 | 253 | 10692 | 0.0237 | -0.3195 |
| MCF 10A | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 962 | 254 | 10512 | 0.0242 | -0.3207 |
| Hs 578T | A443654 | 10 | uM | LJP6 | 72 | hr | 658 | 258 | 3761 | 0.0686 | -0.3111 |
| MDA-MB-231 | AT-7519 | 10 | uM | LJP6 | 72 | hr | 1235 | 259 | 4405 | 0.0584 | -0.5826 |